One of our biggest fears in humanity is change that is out of our control, and Danny Boyle’s 28 Days Later deals with that on a massive scale for lead Jim (Cillian Murphy) as he wakes from a coma in a deserted St Thomas’ Hospital, London. As he leaves the hospital, he finds the streets of London empty – something so sinister, something portraying a disaster of epic proportions. It really is very unsettling. You’re put slap bang in Jim’s shoes as you know how you would feel in his situation.